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Personalized Health Care

P4 Medicine is Personalized Health Care

Ohio State's Wexner Medical Center is committed to advancing personalized healthcare

The Ohio State University Wexner Medical Center Founding Member of P4 Medicine Institute

The Ohio State University Wexner Medical Center is one of the founding members of the P4 Medicine Institute.

The Institute is the country’s only non-profit research organization de​dicated to accelerating the emergence and adoption of health care that is predictive, preventive, personalized and participatory (P4 Medicine) and its impact on our society.

Under the leadership ​of Drs. Lee Hood and Fred Lee, the Institute’s goal is to bring together resources and capabilities from industrial, academic, federal and public sector entities that share a common interest in developing and implementing personalized medicine.

As the emphasis of health care shifts to prediction and prevention, health and wellness and engagement and empowerment, the P4 Medicine Institute will adopt game-changing strategies to transform health care so that it costs less, provides higher quality outcomes and yields better patient satisfaction.

Ohio State's Medical Center will serve as the clinical demonstration site to the P4 Medical Institute’s pilot projects to test collaborative and innovative ideas and technologies that will transform the health care industry.

Some of the concepts that will be tested here include evaluating the use of personal clinical data for health care delivery and research, creating and commercializing intellectual property and piloting a health risk and behavior stratification model to identify patients with different health and wellness needs.

Through this partnership, Ohio State's Wexner Medical Center will have access to new resources, innovations and funding to further our mission of improving people’s lives through personalized health care. And the central Ohio community will be the first in the country to experience a predictive, preventive, personalized and participatory model of care, right here at the Wexner Medical Center at Ohio State.

To learn more, visit:
Personalized Health Care Blog
Dr. Gabbe Video Blog

Here are just a few examples of how we are utilizing P4 Medicine at Ohio State's Medical Center today:

SNP Genotyping

In biochemistry, a nucleotide is a group of molecules that link to form the building blocks of DNA or RNA. A single nucleotide polymorphism (SNP) is a variation of one nucleotide at a specific location in the genome. The human genome contains more than 3 million SNPs that are important genetic markers for determining an individual’s susceptibility to disease and response to drugs. Clinical application of SNP genotyping represents a vital step in the implementation of P4 medicine. At Ohio State, a research team has developed and analytically validated many methods for genotyping medically important SNPs, such as for determining warfarin drug sensitivity and for influencing Tamoxifen or Plavix drug responses. These genotyping tests are ready for clinical application at Ohio State's Wexner Medical Center.

Pharmacogenomics in Drug Therapy

A key aspect in the P4 Medicine effort at Ohio State is applying pharmacogenomics to optimize drug therapy for individual patients. A growing number of drug therapies are linked to pharmacogenomic biomarkers, and there is strong evidence that their use improves clinical outcomes. Genotyping of CYP2C9 and VKORC1 – genes that affect response to an anticoagulant called warfarin – has become the poster child of pharmacogenomics applications.

A recent study showed a nearly 30-percent reduction in hospitalizations when the biomarker test was applied to a large number of patients requiring anticoagulation therapy. Research in Ohio State’s Pharmacogenomics Program has validated the preferred genotyping assay by resolving the mechanism by which the responsible genetic variant alters VKORC1 in the liver.

Also at Ohio State, and with support from the Pharmacogenomics Program, a project is being planned to provide pharmacogenomic test results to all members of the OSU healthcare system. Availability of such information, in anticipation of future need, is likely to overcome an obstacle to clinical implementation, namely the cost of each test and the need to order it ad hoc. Instant access to such information will be critical for implementing genetic biomarker testing in clinical medicine.

P4 Medicine and OSUMyChart

OSUMyChart users become more active participants in their health by accessing key portions of their electronic medical chart (appointments, prescription renewals, allergies, lab results, etc). This online connection to their healthcare provider’s office allows them to communicate easier and more often with their care team to discuss their health status and personalized care plan. With P4 Medicine, innovative tools like OSUMyChart will be needed to help educate patients about their genetic health and decide about preventive steps they can take to improve their wellness and avoid illness. OSUMyChart is playing a key role in providing the transparency and access needed to share this new health opportunity.

Leveraging mobile technology

In an effort to improve the quality of education and patient care, Ohio State’s medical students have been using the Apple iPod Touch since 2007 to assist with their academic and clinical activities. Each student receives a device equipped with medical software programs developed by faculty at Ohio State’s College of Medicine.

At the bedside, patients can take a more participatory role in their own care. Students have the ability to compare symptoms and patient histories to journal articles and medical literature in real time, allowing for more predictive care and greater opportunities to prevent the onset of chronic disease.

Medical students at Ohio State also use the portable media players to personalize their course studies, condensing classroom material and lengthy lectures through a process that removes breaks and pauses, giving students access to the information they need at the speed they want. All lectures in Ohio State’s Meiling Hall auditorium are also recorded and uploaded to iTunes U, a password-protected site where medical students can view lectures on computers or download them to iPods and iPhones.

Representatives from Apple have visited Ohio State to see how medical students were using their product for medical education, as part of Apple’s “Profiles in Medicine.”

Your Plan For Health Participation Aids Prevention

Ohio State’s “Your Plan for Health,” launched in 2006 by the strategic partnership of the Ohio State University Wexner Medical Center, Ohio State University’s Office of Human Resources, and OSU Managed Health Care Systems, Inc., is an ideal pilot test site for personalized health care programs. The goals of “Your Plan for Health” (YP4H) are to improve overall health and increase productivity of faculty and staff through timely preventive care and wellness programs at the individual level; to provide an overall benefits package that will help make The Ohio State University an employer of choice; and to gain control over rapidly rising health care costs, while preserving quality, continuity, and affordability of health care for the university and its faculty and staff. The program and its enhanced benefits are developed under the principles personal empowerment, holistic health management, and personalized health care.

Cheri McMunn, an administrative assistant at Ohio State, is one of thousands of Ohio State employees who participate in YP4H every year. To help determine her personal health needs, Cheri completed a biometric health screening that included measurements of blood pressure, cholesterol, glucose, weight and height.

To Cheri’s surprise, she learned that her cholesterol and blood pressure levels were dangerously high. “I was totally unaware that I had any problem,” she stated.

She contacted her Ohio State physicians, who advised her on what she should do to prevent major health problems. Cheri then had two separate procedures: one to clear a blocked carotid artery and the other to remove coronary artery blockages.

Cheri and her physicians deemed the results life-changing and potentially lifesaving.

Annual Personalized Health Care National Conference at Ohio State​

The Ohio State University Wexner Medical Center will host our national conference on personalized health care in October.

This conference is one of the most dynamic and interactive annual discussions among international healthcare leaders, government policy-makers, healthcare providers, researchers, industry experts, academic leaders, and consumer-advocacy groups on the subject of Personalized Health Care and P4 Medicine and it’s all happening at here, at Ohio State.

For more information about the 2012 Ohio State Personalized Health Care National Conference, visit cphc.osu.edu