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Comprehensive Wound Center   

Chandan Sen, PhD, FACN, FACSM, Executive Director

Each month, approximately 1,200 patients with chronic, non-healing wounds receive advanced, research-based care at Ohio State’s Comprehensive Wound Center (CWC), which opened in 2005 at the Martha Morehouse Medical Plaza under the direction of Executive Director Chandan Sen, PhD. The CWC is a hub for wound sciences and care, a place where National Institutes of Health (NIH)-funded basic research meets clinical application as the fundamental principles of wound healing, starting at the genetic level, are translated from the lab to the bedside. The program is co-led by highly recognized wound care physicians such as Richard Schlanger, MD, PhD, clinical scientists such as Gayle Gordillo, MD, and genomics experts such as Sashwati Roy, PhD.

Ongoing Research Programs
  • The CWC is an integral component of Ohio State’s National Institutes of Health Center for Clinical and Translational Sciences (CCTS). Chandan Sen, PhD, directs the Novel Clinical and Translational Methodologies Program of the CCTS. Sen, a professor of Surgery and of Molecular and Cellular Biochemistry, is on the board of directors of the National Wound Healing Society.
  • In 2007, the CWC began its first placebo-controlled, randomized clinical trial addressing wound-healing therapeutics. In partnership with National Healing Corporation, a Florida-based wound-care management company, the CWC is conducting multicenter clinical studies supported by Ohio State’s bioinformatics infrastructure, the Information Warehouse.
  • CWC patient care is based on comprehensive treatment protocols that stem from research and employ techniques such as hyperbaric oxygen therapy, topical oxygen therapy, transcutaneous oxygen monitoring to determine vascular problems and promote spontaneous healing, negative pressure therapy for accelerated wound healing, and synthetic growth factors and tissue coverings.
  • On average, more than 70 wound-care physicians from throughout the United States come to Ohio State each month for advanced training and education. In 2009, the Mathematical Biosciences Institute of Ohio State will host a conference titled Mathematical Modeling of Wound Healing. Supported by the National Science Foundation, this conference will be chaired by Sen and Professor Philip Maini of Oxford University in London.

.Research Accomplishments of 2007
  • Scientists reported a novel technique based on laser capture for the genomic study of blood vessels isolated from human wound biopsy tissues.
  • Scientists noted for the first time that human wounds can be topically oxygenated toward beneficial clinical outcome.
  • Researchers characterized novel pathways involved in oxygendependent differentiation of fibroblasts to myofibroblasts.
  • Scientists demonstrated for the first time that microRNA may regulate wound healing.
  • Scientists demonstrated that wound lactate may stimulate angiogenesis.