2004 Department-Based Research 

DEPARTMENT OF ANESTHESIOLOGY –
Daniel Sedmak, MD, Interim Chair

The Department of Anesthesiology research infrastructure has grown to include 44 members made up of faculty, research staff and students from 14 different departments, divisions or institutions at OSU. Significant areas of research during 2002-2003 include:

• Purinergic regulation of enteric neural reflexes – Fedias Christofi, PhD
• Redox mechanisms of respiratory muscle stress adaptation– Thomas Clanton, PhD
• Mechanisms of altered vasoreactivity in scleroderma – Fedias Christofi, PhD and Nicholas Flavahan, PhD

DEPARTMENT OF BIOMEDICAL INFORMATICS
Joel Saltz, MD, PhD, Chair

• Biomedical Informatics Synthesis Platform (BISP) – Joel Saltz, MD, PhD; Charis Eng, MD, PhD; Wolfgang Sadée, Dr.rer.nat; Haifeng Wu, MD; Don Stredney, MA.
• High-level Programming Methodologies for Data-Intensive Computations. Gagan Agrawal, PhD, Joel Saltz, MD, PhD.

DEPARTMENT OF FAMILY MEDICINE
Mary Jo Welker, MD,

Chair Significant research programs in the department in 2002-2003 include:

• Challenging socioeconomic health disparities: A collaborative podogeriatric plan – Lawrence Gabel, PhD
• Ohio Regional Center for Agricultural Disease and Injury Research, Education and Prevention – Lawrence Gabel, PhD
• Ohio State’s family medicine curriculum: CASE (Comprehensive Active Student Education) – Douglas Knutson, MD, Lawrence Gabel, PhD A four-track university-anchored community- oriented residency – William Miser, MD, Lawrence Gabel, PhD
• A four-track university-anchored community-oriented residency – William Miser, MD,Lawrence Gabel, PhD
• The Ohio State Primary Care Academic Institute – Mary Jo Welker, MD, Lawrence Gabel, PhD
• Building research capacity: enhancing research productivity – Mary Jo Welker, MD, Lawrence Gabel, PhD

DEPARTMENT OF INTERNAL MEDICINE
Michael Grever, MD, Chair

The Department of Internal Medicine comprises 12 divisions, each renowned for innovations in patient care, research and education. Synergy among these divisions is reflected in a new $9.5 million Program Project grant from the National Cancer Institute linking oncologists and immunologists to study cancer immunotherapies. In addition, the following significant division grants were received in 2002-2003:

Division of Cardiovascular Medicine –
William Abraham, MD, Director

• Action A CHF Trial investigating outcomes of exercise – William Abraham, MD
• Paradigm shifts in clinical ischemia detection – Philip Binkley, MD
• Redox regulation of arteriole function – Nicholas Flavahan, PhD
• Mechanisms of altered vasoreactivity in scleroderma – Nicholas Flavahan, PhD
• Study comparing the effects of atorvastatin versus pravastatin on the progression and quantification of coronary atherosclerotic lesions as measured by intravascular ultrasound – Raymond Magorien, MD
• Monocyte recruitment: A strategic target in angiogenesis – Nicanor Moldovan, PhD
• EPR/NMR co-imaging of free radicals – Jay Zweier, MD
• Measurement of free radical generation in the heart – Jay Zweier, MD
• Spectroscopy and Imaging – Jay Zweier, MD
• Oxyradicals and nitric oxide in postischemic injury – Jay Zweier, MD

Division of Endocrinology, Diabetes and Metabolism
Kwame Osei, MD, Director

• Arthr/Musc Skel Clinical Center-Osteoarthritis Initiative – Rebecca Jackson, MD
• CRNF RSR: Center for Stress and Wound Healing – Core D Endocrinology Core – William Malarkey, MD
• Stress, aging and wound healing – Core D Endocrinology Core – William Malarkey, MD
• Exercise and energy/substrate utilization in blacks – Dara Schuster, MD
• Clinical trial and observational study, Women’s Health Initiative – Rebecca Jackson, MD
• General Clinical Research Center – William Malarkey, MD
• Preventing Cardiovascular Disease in Diabetes – Kwame Osei, MD

Division of General Internal Medicine
Robert Murden, MD, Director

• Ohio State’s four-year family medicine curriculum: CASE (Comprehensive Active Student Education) – Cynthia Kreger, MD
• The Ohio State Primary Care Academic Institute – Robert Murden, MD

Division of Hematology/Oncology
Michael Caligiuri, MD, Director

• Cancer and leukemia group B (CALGB) – The Ohio State University – Clara Bloomfield, MD
• OSU Comprehensive Cancer Center support grant – Michael Caligiuri, MD
• IL-15 characterization through experimental immunology – Michael Caligiuri, MD
• Therapy for AIDS central nervous system lymphoma – Michael Caligiuri, MD
• Oncology training grant – Michael Caligiuri, MD
• Innate immunity: elucidation and modulation for cancer therapy, projects 1-4 and Cores A-D – Michael Caligiuri, MD
• CALGB – Correlative sciences in leukemia and lymphoma – Michael Caligiuri, MD
• Phase I trials of anti-cancer agents – Michael Grever, MD
• Chronic lymphocytic leukemia research consortium: novel pharmacologic agents in chronic
• lymphocytic leukemia – Michael Grever, MD
• Biological modifier therapies in AIDS malignancies – Manisha Shah, MD
• Translational research in lung cancer – Miguel Villalona, MD

Division of Human Genetics Charis
Eng, MD, PhD, Director

• RET-receptor complex polymorphisms and Hirschsprung disease – Charis Eng, MD, PhD
• Genetics of PTEN in Cowden and related syndromes and familial cancer – Charis Eng, MD, PhD
• Genetics of PTEN and molecular-based patient care, Doris Duke Distinguished Clinical Scientist Award – Charis Eng, MD, PhD
• Genetic and epigenetic alterations in clinical outcome in squamous cell carcinoma of the head and neck – Joel Saltz, MD, PhD

Division of Immunology
Ronald Whisler, MD, Director

• How FcRn prolongs IgG lifespan – Clark Anderson, MD
• How antibodies work: the Fc gamma RI molecular complex – Clark Anderson, MD
• IgG placental transport: endothelial caveolae – Clark Anderson, MD
• Pain, supraspinal serotonin and neurotropic factors – Kevin Hackshaw, MD
• Cellular mechanisms of human immunosenescence – Ronald Whisler, MD
• Clinical centers for the osteoarthritis initiative- patient care – Ronald Whisler, MD / Kevin Hackshaw, MD

Division of Infectious Diseases
Larry Schlesinger, MD, Director

• Adult AIDS Clinical Trials Unit – Susan Koletar, MD
• HIV Vaccine efficacy trials – Michael Para, MD
• Conduct and evaluation of ongoing phase III HIV vaccine efficacy trials – Michael Para, MD

Division of Nephrology
Brad Rovin, MD, Director

• Genetic and clinical risk for human SLE nephritis – PO1 – Lee Hebert, MD; Daniel Birmingham, PhD; Brad Rovin, MD; Chack- Yung Yu, D.Phil.

Other notable 2002-2003 research accomplishments in the Division of Nephrology include:

• Characterization of the urine proteome in patients with inflammatory glomerulonephritis with the goal of identifying novel clinical biomarkers. Brad Rovin, MD.
• The use of biodegradable, micro-sized gelatin particles for delivery of therapeutic genes to treat glomerular kidney disease. N. Stanley Nahman, Jr., MD.

Division of Pulmonary, Critical Care and Sleep Medicine
Clay Marsh, MD, Director

• Redox mechanisms of respiratory muscle stress adaptation – Thomas Clanton, PhD
• Fibroproliferative ARDS Mechanisms of cell death and repair – Ruari Fahy, MD
• Mechanisms of chronic pathobiology in allografts – Clay Marsh, MD
• An Akt target and regulator of monocyte survival – Clay Marsh, MD
• A new paradigm for fibrosis: monocyte activation of TGF – Clay Marsh, MD
• Intracellular pathways regulating monocyte survival – Clay Marsh, MD
• Innate immune cell therapy with stem cell transplants in lymphoma – Susheela Tridandapani, PhD
• HIV surveillance affects macrophage function – Mark Wewers, MD
• Macrophage HIV infection in the lung microenvironment – Mark Wewers, MD
• Molecular mechanism of lung inflammation – Mark Wewers, MD

DEPARTMENT OF MOLECULAR AND CELLULAR BIOCHEMISTRY
Russell Hille, PhD, Interim Chair

• Effect of daily exercise on cardiac autonomic regulation – George Billman, PhD
• ATF3 in beta cell signaling, expression and destruction – Tsonwin Hai, PhD
• Phase I trials of anti-cancer agents – Samson Jacob, PhD, Mark Parthun, PhD, Michael Grever, MD

DEPARTMENT OF MOLECULAR VIROLOGY, IMMUNOLOGY AND MEDICAL GENETICS
Caroline Whitacre, PhD, Chair

The Department of Molecular Virology, Immunology and Medical Genetics is composed of 21 faculty with primary appointments and 42 faculty from other departments who hold joint appointments. The department includes faculty who specialize in the research areas of virology, microbial pathogenesis, immunology and genetics. The genetics faculty are organized as the Division of Human Cancer Genetics, which represents the research arm of the Comprehensive Cancer Center’s Human Cancer Genetics Program. This department ranks in the top quartile of microbiology departments in the U.S. for NIH funding.

Significant programs for 2002-2003 in this department included 37 projects exceeding $350,000 in funding.

• An NIH Program Project grant and NIH Center Grant in the area of stress and wound healing were awarded to Ronald Glaser, PhD, as PI with Caroline Whitacre, PhD, Phillip Popovich, PhD, from MVIMG and collaborating faculty from other units.
• A Biomedical Research and Technology Transfer grant was awarded to Albert de la Chapelle, MD, PhD, for Genetics of Gastrointestinal Cancer.
• An NIH Training Grant in Integrative Immunology was awarded to Virginia Sanders, PhD.
• National Cancer Institute (NCI) grants were awarded for the following programs:
  – Molecular screening for hereditary cancer to Albert de la Chapelle, MD, PhD
  – NF-?B regulation of cancer cachexia to Denis Guttridge, PhD – E2F in cell proliferation and apoptosis to Gustavo Leone, PhD
  – DNA methylation in cancer to Christoph Plass, PhD – Genetics and chemoprevention of lung cancer to Ming You, MD, PhD
• NIAID, NIGMS, or NINDS (all NIH) grants were awarded for the following programs:
  – Neuromodulation of the immune response to Virginia Sanders, PhD
  – Interference in cytokine signalling by mycobacteria to William Lafuse, PhD
  – Mechanisms of HIV-1 variation to Louis Mansky, PhD
  – Mechanisms of Herpes simplex replication to Debbie Parris, PhD
  – Immune response in spinal cord injury to Phillip Popovich, PhD
  – Gene expression in Candida albicans infection to Paula Sundstrom, PhD

The following awards are noted for 2002-2003:

• Albert de la Chapelle, MD, PhD - Member of the National Academy of Sciences
  – William Allan Award from the American Society of Human Genetics
  – Mauro Baschirotto Award from the European Society of Human Genetics
  – Fellow, American Association for the Advancement of Science
• Ronald Glaser, PhD - Named one of the World’s Most Cited Authors by The Institute for Scientific Information (ISI)
  – Director of the NIH-designated Mind- Body Center
  – Fellow, American Association for the Advancement of Science
• Gustavo Leone, PhD - Pew Scholar
• Christoph Plass, PhD - Leukemia/Lymphoma Scholar
• Paula Sundstrom, PhD - Burroughs Wellcome Scholar in molecular pathogenic mycology
• Denis Guttridge, PhD - V Foundation Scholar
• Phillip Popovich, PhD - Departmental Teaching Award
• Robin Parihar - Susan B. Komen Fellowship
• Jeni Prosperi - Susan B. Komen Fellowship

DEPARTMENT OF NEUROLOGICAL SURGERY
E. Antonio Chiocca, MD, PhD, Chair

2002-2003 research programs include:

• Behavioral and neuroendocrine modulation in spinal cord injury model – Ronald Glaser, PhD
• Neurotrophins and transplants in spinal cord injury – Bradford Stokes, PhD

DEPARTMENT OF NEUROLOGY
Jerry Mendell, MD, Chair

2002-2003 research programs and achievements include:

• Semantic network flexibility modulation and autism spectrum – David Beversdorf, MD
• Gentamicin trials in muscular dystrophies – Jerry Mendell, MD
• An analysis of research on neuropathy pain treatment by OSU researchers, published in the March 27, 2003 issue of The New England Journal of Medicine, suggests that most medications cannot relieve pain by more than 30 to 50 percent. The authors propose that seizure medications as an excellent starting point for most patients. Jerry Mendell, MD, and Zarife Sahenk, MD, PhD.

DEPARTMENT OF NEUROSCIENCE
Michael Beattie, PhD, Chair

2002-2003 Neuroscience research program highlights include:

• A study of the role of oxidized RNA in ALS and Alzheimer’s disease – Glenn Lin, PhD
• Work on the transplantation of glial precursor cells in the repair of spinal cord injury – Michael Beattie, PhD and Jacqueline Bresnahan, PhD
• Studies of a zebrafish model of spinal muscular atrophy – Christine Beattie, PhD and Arthur Burghes, PhD – Cellular and Molecular Biochemistry
• Discovery of a role for tumor necrosis factor in synaptic transmission – Michael Beattie, PhD, and Jacqueline Bresnahan, PhD, with colleagues at Stanford University
• Studies of the role of synaptic transmission in setting circadian rhythms – Karl Obrietan, PhD
• Work on the role of RNA transport in neural function – projects by John Oberdick, PhD, and Richard Burry, PhD
• Live cell imaging of axonal transport showing that ‘slow’ transport is rapid but periodic – Anthony Brown, PhD
• The characteristics of ion channels – John Enyeart, PhD, John Oberdick, PhD, and Michael Zhu, PhD

DEPARTMENT OF OBSTETRICS AND GYNECOLOGY
Larry Copeland, MD, Chair

The Department of Obstetrics and Gynecology is composed of five divisions: General Obstetrics and Gynecology; Gynecologic Oncology; Maternal-Fetal Medicine; Reproductive Biology and Vaccine Research; and Reproductive Endocrinology and Infertility.

2002-2003 research programs and achievements include:

• Women’s Health Initiative, Multi-Center Clinical Trials and Observational Studies – Michael Blumenfeld, MD
• Multi-center Network of Maternal Fetal Medicine Units – Jay Iams, MD
• Jay Iams, MD, was OSU investigator in a multicenter national study of 17 alphahydroxyprogesterone caproate (17P) in preterm delivery, which published its findings in the June 22, 2003 issue of The New England Journal of Medicine. The research found that weekly injections of 17P substantially reduced the rate of recurrent preterm delivery and reduced the likelihood of several complications in infants.
• Novel peptide therapeutic approaches for immune tolerance – Pravin Kaumaya, PhD – Molecular Virology, Immunology and Medical Genetics

DEPARTMENT OF OPHTHALMOLOGY
Paul Weber, MD, Chair

Faculty research in the William H. Havener Eye Center, Department of Ophthalmology covers a wide range of topics, both basic and applied, from biology to engineering.

Significant 2002-2003 grants include:

• Modulation of angiogenesis in ocular disease – Robert Chambers, DO
• Collaborative ocular melanoma study – Robert Chambers, DO
• Modulation of angiogenesis in ocular disease – Frederick Davidorf, PhD
• A prospective, randomized, comparative trial to evaluate the safety and effectiveness of the Technolas 217 A Excimer Laser and VISX S3 Laser using LASIK (Laser in situ Keratomileusis) for the correction of -1.00 to -7.00D of myopia with up to 3 diopters of astigmatism – Richard Lembach, MD
• Topographic processing and analysis for CLEK– Cynthia Roberts, PhD

DEPARTMENT OF PATHOLOGY
Michael Bissell, MD, PhD, MPH, Interim Chair

The department’s national standing was substantially advanced by grant awards for the academic year 2002-2003 having exceeded $12 million, twice as much as in prior years. In addition, the department welcomed Joel Saltz, MD, PhD, chair of the Department of Biomedical Informatics, as vice-chair for Pathology for Informatics Research, an appointment that will advance pathology informatics initiatives.

Significant research grants and achievements in 2002-2003 include:

• Cooperative tissue bank of HIV-positive malignancies – Leona Ayers, MD
• Development of human lymphohematopoietic cell production system – Larry Lasky, MD
• Cooperative Human Tissue Network – Daniel Sedmak, MD, and Scott Jewell, PhD
• Rescuing high avidity T cells for prostate cancer immunotherapy – Pan Zheng, MD, PhD
• Lymphohematopoietic cell production – Larry Lasky, MD
• Cancer and leukemia group B (CALGB) pathology coordinating office – Saul Suster, MD
• Ohio State researchers will partner with colleagues from Case Western Reserve University as part of an Ohio Biomedical Research and Technology Transfer (BRTT) grant designed to create a Center for Stem Cell and Regenerative Medicine. Larry Lasky, MD, Pathology, Allied Medical Professions and Internal Medicine, is principal investigator for the project at Ohio State.

DEPARTMENT OF PEDIATRICS
Thomas Hansen, MD, Chair

OSU faculty members participate in pediatric research through the Columbus Children’s Research Institute (CCRI), located on the campus of Columbus Children’s Hospital. The majority of CCRI investigators hold primary appointments in the Department of Pediatrics, OSU College of Medicine and Public Health.

Eight Centers of Emphasis distinguish CCRI as a leading national pediatric research facility:

• Center for Biopathology – a tissue and data repository
• Center for Cell and Vascular Biology – focused research on the prevention and treatment of neonatal necrotizing enterocolitis
• Center for Childhood Cancer – an extension of Ohio State’s Comprehensive Cancer Center focused on pediatric cancers
• Center for Developmental Pharmacology and Toxicology – study of the effects, both beneficial and toxic, of therapeutic agents and environmental chemicals in children, especially premature newborns
• Center for Gene Therapy – focuses on the use of genes to treat and prevent human disease
• Center for Injury Research and Policy – focus on the reduction of death and disability due to childhood injury
• Center for Molecular and Human Genetics – molecular and genetic approaches to the study of congenital malformations and inherited diseases in children
• Center for Vaccines and Immunity – focuses on the control of bacterial and viral diseases through the development of safe and effective vaccines

In addition, more than $39.63 million has been awarded in grants to OSU pediatric faculty. The following were significant in 2002- 2003:

• Close to Home Physician Care Center – Olivia Thomas, MD
• Family AIDS clinic and educational services (FACES) – Michael Brady, MD
• Movable equipment for improved vaccine research – Christopher Walker, PhD
• International AIDS vaccine initiative – Philip Johnson, MD
• Determinants of H. influenzae in otitis media – Lauren Bakaletz, PhD
• Child health research career development awards – Thomas Hansen, MD
• HCV-specific T-cell responses in chimpanzees – Christopher Walker, PhD
• HCV replication and immunity in chimpanzees – Christopher Walker, PhD
• Post-concussive symptoms in children with mild head injury – Christopher Walker, PhD
• Primate core for testing VEE-based SIV vaccines – Philip Johnson, MD

DEPARTMENT OF PHARMACOLOGY
Wolfgang Sadée, Dr.rer.nat, Chair

• A phase 1 study to evaluate the safety and tolerability of HXA tablet in healthy subjects – Glen Apseloff, PhD, Daniel Mullet, PhD
• Phase 1 study to determine optimal configuration of ALGRX3268, AlgoRX Pharm – Glen Apseloff, PhD, Daniel Mullet, PhD
• Mechanisms of action and chemopreventive agents in oral epithelial cells. Molecular events in progression/prevention of oral cancer – Steven D’Ambrosio, MD
• Gene-specific mutations in skin induced by peroxynitrite – Steven D’Ambrosio, MD
• RPTPrho: a novel receptor protein tyrosine phosphatase – Andrej Rotter, PhD

DEPARTMENT OF PHYSICAL MEDICINE AND REHABILITATION
William Pease, MD, Chair

Faculty within the department are actively involved in clinical and basic science research in the areas of traumatic brain injury, spinal cord injury, stroke, bone and mineral metabolism and electrodiagnostic medicine.

Significant grants for 2002-2003 include:

• Ohio Regional Traumatic Brain Injury Model System – John Corrigan, PhD
• Substance abuse treatment compliance for persons with brain injuries – John Corrigan, PhD
• Increasing substance abuse treatment compliance for persons with traumatic brain injury – John Corrigan, PhD
• Bone mass and nutritional status of children with fracture – Velimir Matkovic, MD, PhD
• Osteoarthritis initiative clinical center – Jerry Mysiw, MD
• Traumatic Brain injury model systems – Jerry Mysiw, MD
• A double-blind placebo-controlled trial exploring the efficacy of nortriptyline and amantadine in the management of posttraumatic agitation– Jerry Mysiw, MD
• Ohio Regional Traumatic Brain Injury Model System – Jerry Mysiw, MD
• NIH National Institute on Disability and Rehabilitation Research study on the coordination of care of adult brain injury patients from the time of injury through recovery and rehabilitation. John Corrigan, PhD.

DEPARTMENT OF PHYSIOLOGY AND CELL BIOLOGY
Muthu Periasamy, PhD, Chair

Major areas of research in the department for 2002-2003 include:

• Cardiovascular disease – Muthu Periasamy, PhD, Paul Janssen, PhD, George Billman, PhD, Jack Rall, PhD, and Mark Ziolo, PhD
• Spinal cord diseases – Bradford Stokes, PhD, Lyn Jakeman, PhD
• Neural control – Jack Wood, PhD, Jack Boulant, PhD, Robert Stephens, PhD
• Cell and molecular biology – Beth Lee, PhD, Sissy Jhiang, PhD, John Robinson, PhD, and Dale Vandré, PhD

2002-2003 grants include:

• Effect of daily exercise on cardiac autonomic regulation – George Billman, PhD
• Neuronal control of temperature regulation – Jack Boulant, PhD
• SR CA ATPase a determinant of cardiac contractility – Muthy Periasamy, PhD
• Facilities of research in spinal cord injury – Bradford Stokes, PhD

DEPARTMENT OF SURGERY
E. Christopher Ellison, MD, Chair

The Department of Surgery includes nine surgical specialty divisions: cardiothoracic, general, general vascular, neurological, pediatric, plastic, oncology, transplantation and urology. In addition, the OSU Center for Minimally Invasive Surgery (see page 12) is a multidisciplinary organization within the department.

Research efforts focus on three major areas: wound healing, vascular biology and transplantation and tumor biology. Total research funding received by the department from July 1, 2002-June 30, 2003 was more than $7.4 million, an increase of 32 percent over the previous year. The department ranks among the top 25 U.S. academic surgery departments in NIH funding.

Significant research grants and achievements in 2002-2003, by division, include:

Division of Cardiothoracic Surgery
Robert Michler, MD, Director

• Surgical treatment for ischemic heart failure (STICH) – Robert Michler, MD
• NIH study comparing medical and surgical heart failure therapies seeking to establish guidelines for their use. Robert Michler, MD, is principal investigator at Ohio State.

Division of General and Minimally Invasive Surgery
W. Scott Melvin, MD, Director

• Bacterial sepsis and reactivation of latent cytomegalovirus – Charles Cook, MD
• Minimally Invasive Heart Surgery Center of Excellence – W. Scott Melvin, MD
• A study of wound healing, inflammation and infection – Chandan Sen, PhD
• Vitamin E neuroprotection: novel molecular mechanisms – Chandan Sen, PhD

Division of Peiatric Surgery
Caniano, MD, Director

• CTGF in hepatic fibrosis – David Brigstock, PhD
• HB-EGF and intestinal ischemia/reperfusion injury – Gail Besner, MD

Division of Surgical Oncology
William Farrar, MD, Director

• A phase 2 study of a selective estrogen receptor modulator (SERM3) (LY353381 HC1) versus tamoxifen versus placebo in premenopausal women with an increased risk for breast cancer – William Burak, MD
• Correlative studies for a phase 1 trial of herceptin plus IL-12 – William Carson, MD
• A phase 2 study of anti-VEGF antibody in melanoma – William Carson, MD
• A program of immune-based treatments for cancer – William Carson, MD
• Study of tamoxifen and raloxifen (STAR) – William Farrar, MD
• Phase 1 trials of anticancer agents – Michael Grever, MD
• Preclinical analysis of DTH in transplant patients – Anne VanBuskirk, PhD
• Rosiglitazone therapy in breast cancer – Lisa Yee, MD

Division of Transplant Surgery
Ronald Ferguson, MD, PhD, Director

• Immunologic tolerance for hepatocyte transplantation – Ginny Bumgardner, MD, PhD
• Study of the efficacy and safety of SDZ RAD tablets versus mycophenolate mofetil as part of triple immunosuppressive therapy – Elmahdi Elkhammas, MD
• Study of FTY720A combined with corticosteroids and full- or reduced-dose Neoral in de novo adult renal transplant recipients – Ronald Ferguson, MD, PhD
• The prevention of acute rejection in de novo renal transplant patients – Ronald Ferguson, MD, PhD
• Dynamic immune assessment in transplant patients – Charles Orosz, PhD
• Mechanisms of allograft tolerance – Charles Orosz, PhD
• Mechanisms of chronic pathobiology in allografts – Charles Orosz, PhD
• The immunobiology of murine allograft acceptance – Charles Orosz, PhD
• Basic mechanisms of chronic allograft rejection – Charles Orosz, PhD

SCHOOL OF ALLIED MEDICAL PROFESSIONS
Stephen Wilson, PhD, Director

The School of Allied Medical Professions (SAMP) offers professional programs in athletic training, health information management and systems, medical dietetics, circulation, medical and radiologic technology, occupational, physical and respiratory therapy, and an undergraduate health sciences major. Students and faculty perform research.

Ongoing research projects include:

• Neural plasticity and recovery of function after spinal cord injury – Michele Basso, EdD
• Role of the reticular formation in the motor control of reaching – John Buford, PhD
• Neural plasticity and recovery of function of the upper extremity after stroke – Deborah Larsen, PhD
• Timeline for the loss of mitochondrial oxidative function following blunt trauma to skeletal muscle: defining the window of opportunity for therapeutic intervention – Mark Merrick, PhD

SCHOOL OF BIOMEDICAL SCIENCE
Caroline C. Whitacre, Ph.D., Director

The School of Biomedical Science, which comprises six basic science departments, promotes state-of-the-art research programs to advance medical knowledge and provide quality education for the next generation of biomedical scientists and health professionals.

For more detail, refer to the departments of Biomedical Informatics; Molecular Virology, Immunology and Medical Genetics; Molecular and Cellular Biochemistry; Neuroscience; Pharmacology; and Physiology and Cell Biology.

SCHOOL OF PUBLIC HEALTH
Stanley Lemeshow, PhD, Dean

Research is an essential component of the School’s mission and goals, complementing teaching and learning objectives. Endeavors include basic and applied topics, as well as research aimed at improving the practice of public health.

2002-2003 research programs include:

• Colorectal screening study – Electra Paskett, PhD
• Chemoprevention studies – Gary Stoner, PhD